{"id":1000579,"date":"2026-05-09T10:46:24","date_gmt":"2026-05-09T10:46:24","guid":{"rendered":"https:\/\/bodyflexpeptides.com\/?post_type=product&p=1000579"},"modified":"2026-05-09T12:33:56","modified_gmt":"2026-05-09T12:33:56","slug":"foxo4-dri","status":"publish","type":"product","link":"https:\/\/bodyflexpeptides.com\/?product=foxo4-dri","title":{"rendered":"FOXO4-DRI"},"content":{"rendered":"

Overview<\/h3>\n

FOXO4-DRI is a synthetic D-retro-inverso peptide engineered to mimic a region of the FOXO4 transcription factor and competitively block the FOXO4-p53 interaction. The D-retro-inverso architecture (D-amino acids in reverse sequence) confers protease resistance while preserving the relevant binding surface.<\/p>\n

Research Background<\/h3>\n

FOXO4-DRI emerged from work by Peter de Keizer and colleagues identifying the FOXO4-p53 axis as a key regulator of senescent cell viability. It has been investigated in research on cellular senescence, vascular aging, fibrosis, age-related testosterone biology, and senolytic pharmacology.<\/p>\n

Storage & Handling<\/h3>\n

Store lyophilized peptide at -20\u00b0C for long-term stability. Once reconstituted with bacteriostatic water, store at 2\u20138\u00b0C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.<\/p>\n

Disclaimer:<\/strong>
\nThis product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.<\/p>\n","protected":false},"excerpt":{"rendered":"

CAS Number:<\/strong> 1338449-58-5<\/p>\n

Overview:<\/strong>
\nFOXO4-DRI is a D-retro-inverso peptide designed to disrupt the FOXO4\u2013p53 interaction and selectively trigger apoptosis in senescent cells, making it a leading reference senolytic.<\/p>\n","protected":false},"featured_media":1000630,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[124,126],"product_tag":[],"class_list":["post-1000579","product","type-product","status-publish","has-post-thumbnail","product_cat-all-peptides","product_cat-single-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=\/wp\/v2\/product\/1000579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1000579"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=\/wp\/v2\/media\/1000630"}],"wp:attachment":[{"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1000579"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=1000579"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=1000579"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/bodyflexpeptides.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=1000579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}