Follistatin 344

Overview

Follistatin 344 (FST-344) is one of the principal splice isoforms of the FST gene, alongside the longer FST-315. It encodes a 344–amino acid glycoprotein that circulates and binds activin, myostatin (GDF-8), and related TGF-β superfamily ligands with high affinity.

Research Background

Follistatin 344 has been studied extensively in research on muscle biology, myostatin pathway pharmacology, and tissue regeneration. It is a leading reference compound for studying inhibition of the activin/myostatin axis.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

Follistatin 344 binds and neutralizes myostatin, activin A, and several other TGF-β superfamily ligands by forming high-affinity complexes that prevent receptor engagement. In skeletal muscle research, sequestration of myostatin removes a key negative regulator of muscle mass, leading to enhanced satellite cell activation, increased protein synthesis, and muscle hypertrophy in animal models. Activin neutralization has additional effects on reproductive endocrinology and inflammation in research systems.

Follistatin 344 is studied in research on muscle biology, myostatin signaling, regenerative biology, fibrosis, and reproductive endocrinology. It is a reference compound for activin/myostatin pathway research.