NAD+

Overview

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in every living cell and is essential to cellular metabolism. It exists in two interconvertible forms — oxidized (NAD+) and reduced (NADH) — that participate in hundreds of redox reactions across central metabolism.

Research Background

NAD+ is widely studied in research connected to aging biology, mitochondrial function, DNA damage response, and circadian regulation. Levels of NAD+ decline with age in many tissues, prompting extensive investigation into the consequences of NAD+ depletion and the effects of restoring NAD+ pools through precursor and direct repletion models in laboratory research.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

NAD+ functions as a central electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation, transferring electrons that drive ATP synthesis. It is also a required substrate for sirtuins (NAD+-dependent deacetylases), PARPs (poly-ADP-ribose polymerases involved in DNA repair), and CD38, linking NAD+ status to gene expression, genomic stability, and immune signaling pathways.

NAD+ is studied across research areas including mitochondrial biogenesis, aging and senescence, neurodegeneration models, metabolic stress, and cellular bioenergetics. It serves as a foundational reference molecule for investigators studying redox biology and energy metabolism.