01 / 01AICAR
50 mg
Research peptide
COA Available Batch Documentation● In Stock
Price$64.99
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an adenosine analog and AMPK activator studied as a research tool in metabolic and exercise biology.
For laboratory research use only. Not for human or animal consumption.
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Additional information
- Full name
- AICAR (Acadesine)
- CAS number
- 2627-69-2
- Molecular formula
- C₉H₁₄N₄O₅
- Molecular weight
- 258.23 g/mol
- Purity
- 99% HPLC
- Form
- Lyophilized powder
Identifiers as printed on the product label. Refer to the lot-specific COA for batch data.
Handling & warranty
Reconstitution Warranty Notice (Research Use Only)
For laboratory research use only. Not for human use.- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution should be performed using the recommended bacteriostatic water and handled according to accepted research practices.
- Any applicable warranty related to reconstitution, sterility or material integrity is subject to the stated handling requirements.
- Use of unsuitable third-party diluents or deviation from provided handling guidance may affect applicable warranty coverage.
01Product details
Overview
AICAR is an analog of adenosine monophosphate (AMP) and a precursor in the de novo purine biosynthesis pathway. As a research tool, it is one of the most widely used pharmacological activators of AMP-activated protein kinase (AMPK).
Research Background
AICAR has been studied in research on energy metabolism, exercise biology, glucose homeostasis, and mitochondrial biogenesis. It is a foundational reference compound for AMPK-targeted research.
Storage & Handling
Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.
Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.
02Mechanism of action
Following cellular uptake, AICAR is phosphorylated to ZMP (AICAR monophosphate), which mimics AMP and activates AMPK. AMPK activation triggers a coordinated metabolic response: increased glucose uptake (via GLUT4 translocation), enhanced fatty acid oxidation, suppression of anabolic processes (protein synthesis, fatty acid synthesis, gluconeogenesis), and stimulation of mitochondrial biogenesis through PGC-1α.
03Research applications
AICAR is studied in research on energy metabolism, AMPK signaling, exercise biology, glucose homeostasis, and mitochondrial function. It is a reference compound for AMPK-pathway research.
04Technical specifications
CompoundAICAR
Full nameAICAR (Acadesine)
Strength50 mg
CAS number2627-69-2
Molecular formulaC₉H₁₄N₄O₅
Molecular weight258.23 g/mol
Research areaMetabolic Research
FormLyophilized powder
Purity99% HPLC (per label)
DocumentationCOA available
05Certificate / documentation
Certificate of AnalysisLot-specific documentation
AvailableCertificates of Analysis are issued per lot. Request the COA for your lot and our team will send it to you by email.
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