GHRP-6

Overview

GHRP-6 is a synthetic 6–amino acid peptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂), one of the earliest members of the growth hormone-releasing peptide class developed by Cyril Bowers and colleagues.

Research Background

GHRP-6 is widely used as a reference GHS in research on the somatotropic axis, ghrelin receptor pharmacology, and appetite/feeding regulation. It is notable for producing pronounced increases in research subjects’ food-seeking behavior in rodent models.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

GHRP-6 binds and activates GHSR-1a on pituitary somatotrophs and hypothalamic neurons. Receptor activation drives Gq/PLC/Ca²⁺ signaling, producing pulsatile growth hormone release. Hypothalamic GHSR-1a activation also stimulates orexigenic NPY/AgRP neurons, accounting for the strong appetite-related effects observed in animal research.

GHRP-6 is studied in research on pituitary GH secretion, ghrelin receptor pharmacology, appetite and feeding behavior, and gastric motility. It is a foundational reference compound in GHS research.