Pinealon

Overview

Pinealon is a short tripeptide composed of glutamic acid, aspartic acid, and arginine (Glu-Asp-Arg, EDR). It is part of the Russian peptide bioregulator class developed by Vladimir Khavinson and colleagues, derived from research on pineal-gland-associated peptide fractions.

Research Background

Pinealon has been studied in preclinical models of neuronal stress, hypoxia, oxidative damage, and age-related cognitive change. Research often examines it alongside related bioregulators such as Epitalon, Cortexin-derived peptides, and Vilon.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

Pinealon is hypothesized to enter cells passively via its small size and to translocate into the nucleus, where studies suggest direct interaction with chromatin and DNA-regulatory regions. Reported effects include modulation of gene expression in neuronal cells, reduction of caspase-3 activity in stress and ischemia models, and decreased oxidative-stress markers in cultured cells.

Pinealon is studied in research on neuroprotection, cellular stress responses, age-related cognitive models, and the broader bioregulator-peptide framework. It is a frequent reference compound in short-peptide epigenetic research.