01 / 01Dermal & Tissue
MT-1
10 mg
Research peptide
COA Available Batch Documentation● In Stock
Price$29.95
Melanotan I (Afamelanotide) is a synthetic 13–amino acid analog of α-MSH with high selectivity for the MC1R receptor, studied for its role in melanogenesis.
For laboratory research use only. Not for human or animal consumption.
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Additional information
- Full name
- Afamelanotide (Melanotan I)
- CAS number
- 75921-69-6
- Molecular formula
- C₇₈H₁₁₁N₂₁O₁₉
- Molecular weight
- 1646.85 g/mol
- Purity
- 99% HPLC
- Form
- Lyophilized powder
Identifiers as printed on the product label. Refer to the lot-specific COA for batch data.
Handling & warranty
Reconstitution Warranty Notice (Research Use Only)
For laboratory research use only. Not for human use.- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution should be performed using the recommended bacteriostatic water and handled according to accepted research practices.
- Any applicable warranty related to reconstitution, sterility or material integrity is subject to the stated handling requirements.
- Use of unsuitable third-party diluents or deviation from provided handling guidance may affect applicable warranty coverage.
01Product details
Overview
Melanotan I, also known as Afamelanotide, is a synthetic linear tridecapeptide modeled on α-melanocyte-stimulating hormone with substitutions ([Nle⁴, D-Phe⁷]-α-MSH) that confer enhanced metabolic stability and high MC1R selectivity.
Research Background
Melanotan I has been studied in research on melanogenesis, photoprotection, and pigmentation biology. Unlike Melanotan II, it is comparatively selective for MC1R and does not strongly engage the MC3/4/5 receptors involved in appetite and sexual behavior.
Storage & Handling
Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.
Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.
02Mechanism of action
Melanotan I binds and activates the melanocortin-1 receptor (MC1R) on melanocytes. MC1R activation engages Gs-coupled cAMP signaling, upregulating MITF (microphthalmia-associated transcription factor), tyrosinase, and TRP-1/2 enzymes responsible for synthesis of eumelanin. The result is increased melanin production and altered pigmentation in skin and hair models.
03Research applications
Melanotan I is studied in research on melanogenesis, photoprotection, MC1R pharmacology, and pigmentation disorders. It serves as a selective MC1R reference compound in melanocortin research.
04Technical specifications
CompoundMT-1
Full nameAfamelanotide (Melanotan I)
Strength10 mg
CAS number75921-69-6
Molecular formulaC₇₈H₁₁₁N₂₁O₁₉
Molecular weight1646.85 g/mol
Research areaDermal & Tissue
FormLyophilized powder
Purity99% HPLC (per label)
DocumentationCOA available
05Certificate / documentation
Certificate of AnalysisLot-specific documentation
AvailableCertificates of Analysis are issued per lot. Request the COA for your lot and our team will send it to you by email.
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