KPV

Overview

KPV is a tripeptide composed of lysine, proline, and valine, derived from the C-terminal residues 11–13 of α-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV retains much of α-MSH’s anti-inflammatory activity without engaging melanocortin receptors at typical concentrations.

Research Background

KPV has been studied in research models of intestinal inflammation, colitis, dermatitis, and immune-mediated tissue injury. It is examined in both topical and systemic-administration research designs.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

KPV is reported to enter cells via the PEPT1 transporter, particularly in intestinal epithelium, and exert intracellular anti-inflammatory effects. It downregulates NF-κB signaling, reduces production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and modulates inflammatory gene expression independently of melanocortin receptor activation.

KPV is studied in research on inflammatory bowel models, skin inflammation, antimicrobial activity, and broader anti-inflammatory peptide signaling. Its small size and oral-stable profile make it a useful research tool for studying α-MSH-derived activity in isolation.