MT-2

Overview

Melanotan II is a synthetic cyclic lactam analog of α-MSH, originally developed at the University of Arizona. It is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R.

Research Background

Research interest in Melanotan II spans pigmentation biology (via MC1R activation in melanocytes), appetite and energy balance (MC3R/MC4R), and sexual behavior pathways (MC4R). It has been studied in both rodent and cell-culture models examining each of these axes.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

Melanotan II binds and activates multiple melanocortin receptors. Activation of MC1R on melanocytes stimulates eumelanin synthesis through the cAMP/PKA pathway. Engagement of MC3R and MC4R in the central nervous system is associated with appetite suppression and altered energy homeostasis, while MC4R activity is also linked to neural pathways involved in sexual response.

Melanotan II is studied across pigmentation, energy balance, and behavioral research models. Its non-selective receptor profile makes it a comparative reference for investigators studying selective melanocortin agonists.