PEG-MGF

Overview

MGF (Mechano-Growth Factor), also called IGF-1Ec, is a splice variant of insulin-like growth factor-1 expressed transiently in skeletal muscle following mechanical loading or injury. The unique C-terminal peptide of MGF (often the studied fragment) confers biological activity distinct from systemic IGF-1. The PEG-MGF version conjugates polyethylene glycol to extend the otherwise very short half-life of the native peptide.

Research Background

MGF has been studied in research on muscle injury and recovery, satellite cell activation, and tissue regeneration. PEGylation is a standard strategy used to make the otherwise rapidly cleared MGF more practical for in vivo research designs.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

The MGF C-terminal peptide is reported to act through a non-IGF-1R-dependent mechanism (its receptor remains incompletely characterized), distinct from the receptor-tyrosine-kinase signaling of systemic IGF-1. Research suggests it activates skeletal muscle satellite cells, promoting their proliferation and resistance to apoptosis, contributing to muscle repair and adaptation following injury or mechanical loading. PEGylation extends plasma half-life by reducing renal clearance and proteolytic degradation.

PEG-MGF is studied in research on muscle injury and adaptation, satellite cell biology, tissue regeneration, and IGF-1 splice variant pharmacology. It is a reference compound in mechano-responsive peptide research.