SLU-PP-332

Overview

SLU-PP-332 is a synthetic small-molecule compound developed at Saint Louis University as an agonist of the estrogen-related receptor (ERR) family of orphan nuclear receptors. It activates all three ERR isoforms with preferential potency at ERRα (EC50 ≈ 98 nM), classifying it as a pan-ERR agonist.

Research Background

SLU-PP-332 has been studied in research on metabolic regulation, exercise mimetics, cardiac function, and mitochondrial biology. Animal model studies have reported induction of an aerobic exercise gene-expression program, increased exercise endurance, and protective effects in heart-failure models.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

SLU-PP-332 binds the ligand-binding domain of ERRα, β, and γ, stabilizing the active receptor conformation and recruiting transcriptional coactivators (notably PGC-1α). This drives expression of genes governing mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. In skeletal muscle, ERRα-dependent induction of DDIT4 and related exercise-responsive genes is reported.

SLU-PP-332 is studied in research on exercise biology, metabolic regulation, mitochondrial function, and cardiac fatty acid metabolism. It is a leading reference compound for ERR-targeted exercise-mimetic research.