01 / 01SS-31
Research peptide
SS-31 (Elamipretide) is a synthetic mitochondria-targeted tetrapeptide (D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH₂) studied for its interaction with cardiolipin and protection of mitochondrial function.
For laboratory research use only. Not for human or animal consumption.
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Additional information
- Full name
- Elamipretide (SS-31)
- CAS number
- 736992-21-5
- Molecular formula
- C₃₂H₄₉N₉O₅
- Molecular weight
- 639.79 g/mol
- Purity
- 99% HPLC
- Form
- Lyophilized powder
Identifiers as printed on the product label. Refer to the lot-specific COA for batch data.
Reconstitution Warranty Notice (Research Use Only)
For laboratory research use only. Not for human use.- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution should be performed using the recommended bacteriostatic water and handled according to accepted research practices.
- Any applicable warranty related to reconstitution, sterility or material integrity is subject to the stated handling requirements.
- Use of unsuitable third-party diluents or deviation from provided handling guidance may affect applicable warranty coverage.
01Product details
Overview
SS-31, also called Elamipretide or MTP-131, is a small tetrapeptide engineered to selectively concentrate in the inner mitochondrial membrane through interaction with cardiolipin. It is part of the Szeto-Schiller (SS) peptide series.
Research Background
SS-31 has been studied in research on mitochondrial dysfunction, ischemia-reperfusion injury, heart failure, neurodegeneration, and age-related decline in mitochondrial bioenergetics.
Storage & Handling
Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.
Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.
02Mechanism of action
SS-31 binds with high affinity to cardiolipin, a phospholipid uniquely concentrated in the inner mitochondrial membrane. This interaction stabilizes cardiolipin-cytochrome c associations, preserves the structure of mitochondrial cristae, supports electron transport chain efficiency, and reduces excessive reactive oxygen species generation. Net effects in research models include preserved ATP production and reduced mitochondrial membrane permeabilization.
03Research applications
SS-31 is studied in research on mitochondrial dysfunction, ischemia-reperfusion injury, heart failure models, neurodegeneration, and aging biology. It is a reference compound in cardiolipin-directed mitochondrial peptide research.
04Technical specifications
05Certificate / documentation
Certificates of Analysis are issued per lot. Request the COA for your lot and our team will send it to you by email.



