Ipamorelin

Overview

Ipamorelin is a 5–amino acid synthetic peptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) and one of the most selective ghrelin receptor agonists in the GHS class. It was developed to retain GH-releasing activity while avoiding effects on cortisol, prolactin, ACTH, and aldosterone.

Research Background

Ipamorelin is widely used as a reference GHS in research on the growth hormone axis, sleep architecture, and metabolic regulation. It has been examined in both isolated form and in combination with GHRH analogs such as CJC-1295.

Storage & Handling

Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.

Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.

Ipamorelin binds the growth hormone secretagogue receptor 1a (GHSR-1a) — the ghrelin receptor — on pituitary somatotrophs and hypothalamic neurons. Receptor activation triggers Gq-coupled phospholipase C signaling, calcium mobilization, and pulsatile growth hormone release. Its high receptor selectivity is responsible for its neutral profile on cortisol and prolactin compared to earlier GHS peptides.

Ipamorelin is studied in research on pituitary GH secretion, body composition, sleep biology, and metabolic regulation. It is a frequent reference compound for selective GHS pharmacology.