01 / 01MOTS-C
10 mg / 20 mg / 40 mg
Research peptide
COA Available Batch Documentation● In Stock
Price Price range: $34.95 through $124.95
MOTS-c is a 16–amino acid mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome, studied for its role in metabolic and mitochondrial signaling.
For laboratory research use only. Not for human or animal consumption.
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Additional information
- Full name
- MOTS-c
- CAS number
- 1627580-64-6
- Molecular formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular weight
- 2174.62 g/mol
- Purity
- 99% HPLC
- Form
- Lyophilized powder
Identifiers as printed on the product label. Refer to the lot-specific COA for batch data.
Handling & warranty
Reconstitution Warranty Notice (Research Use Only)
For laboratory research use only. Not for human use.- Lyophilized peptides should be reconstituted using proper aseptic laboratory technique.
- Reconstitution should be performed using the recommended bacteriostatic water and handled according to accepted research practices.
- Any applicable warranty related to reconstitution, sterility or material integrity is subject to the stated handling requirements.
- Use of unsuitable third-party diluents or deviation from provided handling guidance may affect applicable warranty coverage.
01Product details
Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino acid peptide encoded within mitochondrial DNA and translated from a small open reading frame in the 12S ribosomal RNA region. It is one of the best-characterized mitochondrial-derived peptides (MDPs).
Research Background
MOTS-c has been studied in research on metabolic regulation, insulin sensitivity, exercise biology, and cellular stress responses. Its discovery has expanded the understanding of mitochondria as endocrine-signaling organelles.
Storage & Handling
Store lyophilized peptide at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2–8°C and use within recommended timeframes. Handle under sterile laboratory conditions and avoid repeated freeze-thaw cycles.
Disclaimer:
This product is for laboratory research use only. It is not intended for human or animal consumption or for use in any diagnostic, therapeutic, or clinical applications.
02Mechanism of action
MOTS-c is released from mitochondria into the cytosol and circulation in response to metabolic stress. It modulates AMPK signaling, influencing glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Under stress conditions, MOTS-c translocates to the nucleus, where it associates with stress-response transcription factors (including NRF2) to regulate adaptive gene expression.
03Research applications
MOTS-c is studied in research on insulin sensitivity, metabolic homeostasis, exercise adaptation, mitochondrial biology, and cellular aging. It is a foundational reference for mitochondrial-derived peptide research.
04Technical specifications
CompoundMOTS-C
Full nameMOTS-c
Strength10 mg / 20 mg / 40 mg
CAS number1627580-64-6
Molecular formulaC₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight2174.62 g/mol
Research areaMetabolic Research
FormLyophilized powder
Purity99% HPLC (per label)
DocumentationCOA available
05Certificate / documentation
Certificate of AnalysisLot-specific documentation
AvailableCertificates of Analysis are issued per lot. Request the COA for your lot and our team will send it to you by email.
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